You must first have completed the Built to Last quest. The quest begins when you speak to Commander Clyver, who's at #11 in Crucible Keep. He gives you a Cover of Vianna's Research with the intention that you deliver it to a courier in Anslog's Compass.
*Note* Taking this quest on means committing yourself exclusively to the Knights of the Crucible, and you will not thereafter be able to take on quests for House Doemenal or The Dozens.
The courier, named Aranroed, will be at #12 on the Anslog's Compass map. Both she and your party will get ambushed by members of the Dozens led by Padebald. The fight shouldn't be difficult to win. The loot includes:
Head back to the Crucible Keep. It becomes apparent that the Forge Knights have run amok and turned on their creators, which will force you to destroy them. They leave Swords and Binding Coppers when killed, and may occasionally drop an Awakened Adra or a Shattered Animat Armor.
They will be fighting members of the Knights of the Crucible inside. Don't worry about any Crucible Knights falling, it won't have any consequences. In fact, fallen Crucible Knights will leave behind Swords, Medium Shields, Helms and Plate Armors when killed, and that you can loot and sell.
Find Commander Clyver at his usual spot when the fighting is done. You will have a choice during the ensuing dialogue as to whether to encourage Clyver to stop use of the research to manufacture Forge Knights, or to press on with using the research. Your choice will affect your endgame epilogue, but otherwise will not have any in-game consequences.
You will also get a Talent called Second Skin, which will raise the Damage Reduction of your main character by +2.
You will gain an extraordinary boost of positive reputation with the Knights of the Crucible, and a moderate boost of positive reputation with Defiance Bay.
Lastly, the Knights of the Crucible will become your sponsoring organization for purposes of the upcoming Animancy hearing.
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"*JUSTICE uses Mercykillers as her EYES. JUSTICE uses Mercykillers to dispense her WILL. When SENTENCE is passed, she LENDS us her STRENGTH.*" -Vhailor, Planescape: Torment